张弘  博士 副教授    硕导

通讯地址:

北京市海淀区学院路38号北京大学医学部

邮政编码: 100191

联系电话: 82801589电子邮箱:zhanghong@bjmu.edu.cn

教育及培训经历:

(1) 2000-4至2004-7, 大阪大学, 内科学, 博士, 导师: Hitoshi Kikutani

(2) 1999-8至2000-3, 大阪大学, 内科学, 硕士, 导师: Hitoshi Kikutani

(3) 1988-8至1993-7, 北京医科大学, 临床医学, 学士

工作经历:

(1)2004-12至现在, 北京大学医学部, 心血管研究所, 副教授

(2) 1998-8至1999-7, 北京协和医院, 心内科, 主治医师

(3) 1993-8至1999-7, 北京协和医院, 心内科, 住院医师

研究方向: 心血管发育，血管再生和糖脂代谢

代表性科研论文:

1.Fan YB, Tan DD, Song DY, Zhang X, Chang XZ, Wang ZX, Zhang C, Chan SH, Wu QX, Wu LW, Wang S, Yan H, Ge L, Yang HP, Mao B, Bonnemann C, Liu JY, Wang SX, Yuan Y, Wu XR, Zhang H^＊, Xiong H^＊. The clinical spectrum and genetic variations of LMNA-related muscular dystrophies in a large cohort of Chinese patients. J Med Genet. 2020; jmedgenet-2019-10667. 共同责任作者

2.Fan YB, Tan DD, Zhang X, Song DY, Chang XZ, Wang S, Yan H, Ge L, Yang HP, Bonnemann C, Liu JY, Wang SX, Wu XR, Zhang H^＊, Xiong H^＊. Nuclear factor-κB pathway mediates the molecular pathogenesis of LMNA-related muscular dystrophies. Biochemical Genetics. 2020 Jul 23. 共同责任作者

3.Long Xb, Hou HM, Wang X, Liu SJ , Diao TX , Lai SC, Hu ML, Zhang SQ, Liu M^＊and Zhang H^＊  Immune signature driven by ADT-induced immune microenvironment remodeling in prostate cancer is correlated with recurrence-free survival and immune infiltration. Cell Death and Disease (2020) 11:779 共同责任作者

4.Liu w, Li J, Liu M, Zhang H, Wang N, PPAR-γ promotes endothelial cell migration by inducing the expression of Sema3g. J Cell Biochem.  2015 Apr;116(4):514-23 责任作者

5.Hao, G，Han, Z，Meng, Z，Wei, J，Gao, D，Zhang, H，Wang, N，Ets-1 upregulation mediates angiotensin II-related cardiac fibrosis.，Int J Clin Exp Pathol，2015.01.01，8（9）：10216~10227

6.Zhang H, Li Y, Fan Y, Wu J, Zhao B, Guan Y, Chien S, Wang N. Klotho is a target gene of PPAR-gamma. Kidney Intl 2008; 74:732-9.  本文发现有重大意义，在同期杂志中有评述见同期杂志702页。

7.Fan Y, Wang Y, Zhang H, Qin X, Zhu Y, Guan Y, Wang X, Staels B, Chien S, Wang N. Suppression of Pro-inflammatory Adhesion Molecules by PPAR-d in Human Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol. 2008; 28:315-2.

8.Toyofuku T*, Zhang H*, Kumanogoh A, Takegahara N, Suto F, Kamei J, Kazuhiro A, Yabuki M, Hori M, Fujisawa H, Kikutani H. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with Off-Track and vascular endothelial growth receptor type2. Gene & Development, 2004，18:435-447. （*共同第一作者）文章中的图作为本刊的封面展示

9.Toyofuku T, Yoshida J, Sugimoto T, Zhang H, Kumanogoh A, Hori M, Kikutani H. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci. 2005，8:1712-9.

10.Toyofuku T, Zhang H, Kumanogoh A, Takegahara N, Yabuki M, Harada K, Hori M, Kikutani H. Guidance of myocardial patterning in cardiac development by bi-directional Sema6D signals. Nature Cell Biol, 2004，6:1204-1211. 见同期杂志有专门论述该文章的重大发现

11.Zhang H, Toyofuku T, Kamei J, Hori M. GATA-4 regulates cardiac morphogenesis through transactivation of the N-cadherin gene. Biochemical and Biophysical Research Communications 2003, 312:1033-1038.

12.Toyofuku T, Akamatsu Y, Zhang H, Kuzuya T, Tada M, Hori M. c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. J Biol Chem. 2001, 276:1780-1788.

13.Toyofuku T, Zhang H, Kuzuya T, Tada M, Hori M. Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J Cell Biol. 2000, 150:225-241.