黄薇 博士 副教授 Co-PI 硕士生导师 心血管所副所长

通讯地址：北京市海淀区学院路38号北京大学心血管研究所

邮政编码：100191

联系电话：10-82801589

电子邮箱： huangwei@bjmu.edu.cn

教育背景：

1996-2001：巴黎七大生物医学博士学位（PhD）

1995-1996：巴黎七大生物医学硕士学位 (Master)

1986-1991：华中科技大学同济医学院临床医学学士学位

工作经历：

2018-至今：心血管研究所副所长

2003-至今：北京大学医学部心血管研究所副教授，硕士生导师

2001-2002：法国国家健康医学研究学院U367 (心血管生理病理研究所) 博士后

1991-1993：华中科技大学同济医学院附属协和医院内科住院医师

社会兼职：

中国生理学会副秘书长

中国病生理学会心血管专委会委员

北京生理学会常务理事、北京生理学会心血管病专委会副主任委员

《生理通讯》副主编

《中国医学前沿杂志》及《基础医学与临床》编委

研究方向及基金：

研究方向：脂代谢紊乱在糖尿病血管病变中的作用、机制及治疗研究。包括Seipin， ApoCIII，GPIHBP1及LPL等甘油三酯代谢相关基因在血管、肾及心脏中的作用及机制研究。

已获6项国家自然基金面上项目资助，973骨干两项，863参与一项。

在研基金： 载脂蛋白C3通过促进铁死亡加重血管钙化的作用及机制研究 （国自然面上项目，批准号：82370454，执行期限：2024.01-2027.12）

代表性论文：（#第一作者， * 责任作者）

1．Huang W#., Alhenc Gelas F.and Osborne-Pellegrin M. J. Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat. Circulation Research.1998, 82: 879-90. (IF: 9.8)

2．Huang W#., Gallois Y., Bouby N., Bruneval P., Heudes D., Belair M.F., Krege J.H., Meneton P., Marre M., Smithies O., and Alhenc-Gelas F. Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse . Proc Natl Acad Sci USA. 2001, 98(23):13330-4. (IF: 9.6)

3．Guo J ^#, Miao G ^#, Zhang W^#, Shi H, Lai P, Yi X., Zhang L, Chen G, Han Y, Zhao Y, Liu G, Zhang L, Wang Y, Huang W*, Xian X*. Depletion of ApoA5 aggravates spontaneous and diet-induced nonalcoholic fatty liver disease by reducing hepatic NR1D1 in hamsters. Theranostics. 2024; 14(5): 2036-2057. (IF: 12.4)

4．Liu Z#, Dong L#, Shen G#, Sun Y, Liu Y, Mei J, Jia J, Fan F, Wang W, Huang W*, Li J*. Associations of neutrophil-percentage-to-albumin ratio level with all-cause mortality and cardiovascular disease-cause mortality among patients with hypertension: evidence from NHANES 1999-2010. Front Cardiovasc Med. 2024 Jul 17;11:1397422.（并列责任，IF：6）

5．Zhao J, Han L, Zhang YR, Liu SM, Ji DR, Wang R, Yu YR, Jia MZ, Chai SB, Tang HF, Huang W*, Qi YF*. Intermedin alleviates diabetic cardiomyopathy by up-regulating CPT-1β through activation of the phosphatidyl inositol 3 kinase/protein kinase B signaling pathway. Pharmaceuticals (Basel). 2024 Sep 12;17(9):1204. doi: 10.3390/ph17091204.（并列责任，IF：4.3）

6．Liao J#, Wang Y#, Wang Y, Zhang J, Wu F, Liu G, Huang W*, Zhang Y*. Human ApoC3 overexpression aggravates hyperlipidemia but mitigates diet-induced coronary atherosclerotic disease in SR-BI and LDL receptor double knockout mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr;1869(3):159449. （并列责任,IF：4.0）

7．Liao J, Wang Y, Wang Y, Zhang J, Wu F, Liu G, Huang W*, Zhang Y*. Human ApoC3 overexpression aggravates hyperlipidemia but mitigates diet-induced coronary atherosclerotic disease in SR-BI and LDL receptor double knockout mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Dec 30;1869(3):159449. (IF: 4.8)

8．Wang H, Huang X, Xu P, Liu X, Zhou Z, Wang F, Li J, Wang Y, Xian X, Liu G, Huang W*. Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-κB pathway. Metabolism. 2021 Jun; 119:154740.

(IF: 8.9)

9．Wu XY, Liu XJ, Wang H, Zhou ZH, Yang CZ, Li ZJ, Zhang YY, Shi XL, Zhang L, Wang YH, Xian XD, Liu G, Huang W*. Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice. Frontiers in Cardiovascular Medicine. 2021Mar 11;8: 644128. doi: 10.3389 / fcvm.2021.644128 (IF: 6.05)

10． Liao J, Bai J, An X, Liu Y, Wang Y, Liu G, Huang W*, Xia Y.Lipoprotein Glomerulopathy-Like Lesions in Atherosclerotic Mice Defected With HDL Receptor SR-B1. Front Cardiovasc Med. 2021 Oct 8;8:734824. (IF: 6.05)

11． Wang F, Wang H, Liu X, Yu H, Huang X, Huang W*, Wang G*.Neuregulin-1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase-1 in myocardial ischaemia-reperfusion injury. J Cell Mol Med. 2021Feb;25(3):1783-1795. （IF: 5.31）

12． Liu X#; Li J#; Liao J; Wang H; Huang X; Dong Z; Shen Q; Zhang L; Wang Y; Kong W; Liu G; Huang W*. Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice. Atherosclerosis. 2019, 282: 100-109. (IF: 4.3)

13． Wang H#; Xu PF#; Li JY; Liu XJ; Wu XY; Xu F; Xie BC, ; Huang XM,; Zhou ZH; Kayoumu A; Liu G; Huang W*. Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice. Am J Physiol Endocrinol Metab., 2019, 316(1): E54--E62. (IF: 4.1)

14． Liu XJ#; Wu XY; Wang H; Wang SX; Kong W; Zhang L; Liu G; Huang W*. Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue–kidney crosstalk. FASEB J., 2018, 32(10): 5550-5562.（IF: 5.59）

15． Wang FH#; Wang H; Liu XJ; Yu H; Zuo B; Song Z; Wang N; Huang W*; Wang GS*. Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway. Molecular Medicine. 2018, 24(1): 39-51. (IF: 3.4)

16． Liao J#, Bai J, An X, Liu Y, Wang Y, Liu G, Huang W*, Xia Y*. Lipoprotein Glomerulopathy-Like Lesions in Atherosclerotic Mice Defected With HDL Receptor SR-B1. Front Cardiovasc Med. 2021 Oct 8;8:734824. doi: 10.3389/fcvm.2021.734824. PMID: 34692787; PMCID: PMC8531488.

17． Liao J*; Liu X; Gao M; Wang M; Wang Y; Wang F; Huang W*; Liu G. Dyslipidemia, steatohepatitis and atherogenesis in lipodystrophic apoE deficient mice with Seipin deletion. Gene.2018, 648: 82-88. (IF: 2.6)

18． Liao J* ，Guo X，Wang M，Gao M，Shen Q，Wang, Y，Huang W*，Liu G. Deficiency of scavenger receptor class B type 1 leads to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling，Cardiovasc Pathol，2017, 27：26~30. （IF: 2.5）

19． Liao J#; Guo X; Wang M; Dong C; Gao M; Wang H; Kayoumu A; Shen Q; Wang   Y; Wang F; Huang W*; Liu G. Scavenger Receptor Class B Type 1 Deletion Led to Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor Knockout Mice on Modified Western-type Diet. J Atheroscler Thromb, 2017, 24(2): 133-146. ( IF: 3.0)

20． Xu P, Wang H, Kayoumu A, Wang M, Huang W*, Liu G*.Diet rich in  Docosahexaenoic Acid/Eicosapentaenoic Acid robustly ameliorates hepatic steatosis and insulin resistance in seipin deficient lipodystrophy mice. Nutr Metab. 2015 Dec 18,12:58. (IF: 3.3)

21． Liao J, Gao M, Wang M, Guo X, Huang W*, Liu G*. Spontaneous and diet-aggravated hemolysis and its correction by probucol in SR-BI knockout mice with LDL-R deficiency.BBRC. 2015, 463(1-2):48-53.（IF: 2.8）

22． Guo X, Liao J, Huang X, Wang Y, Huang W*, Liu G* Reversal of adipose tissue loss by probucol in mice with deficiency of both scavenger receptor class B type 1 and LDL receptor on high fat diet. BBRC. 2017 May 15. (IF: 2.6)

23． Zhou XL,Wang ZH, Wang YH，Shen Q，Zhang L，Guan YF，Liu G，Huang W*. Lipoprotein lipase gene deficiency accelerates early renal dysfunctions in type 1 diabetic mice. Chin J Diabetes. 2012 Jan, 20 (1): 61-64.

24． Wu X, Wang J, Fan J, Chen M, Chen L, Huang W*, Liu G*. Localized vessel expression of lipoprotein lipase in rabbits leads to rapid lipid deposition in the balloon-injured arterial wall. Atherosclerosis. 2006 , 187(1):65-73（IF: 3.8）

25． 黄小敏,王富华,刘雪静,周子豪,张玲,刘国庆,黄薇* 载脂蛋白CⅢ通过氧化应激通路促进人肾小球系膜细胞表型转分化 中国生物化学与分子生物学报 2019 Vol.35 (8): 862-869。

26． 刘雪静，王欢，严放，高明明，刘国庆，黄薇*。生理科学进展。2015，46（1）：11-15。大中型动物基因敲除技术的研究进展。

27． Seipin基因缺陷诱发小鼠肾损害。吴晓月，王 欢，刘雪静，廖家葳，张玲，刘国庆，黄薇*。中国病理生理杂志。2014，30（10）：1850-1854。

28． 普罗布考对2型糖尿病动脉粥样硬化的保护作用。王欢，许鹏飞，刘雪静，廖家葳，阿布，刘国庆，黄薇*。中国动脉粥样硬化杂志。2015, 23(7)。

29． 王富华、刘雪静、王欢、左波、宋祝、黄薇和王贵松。神经调节蛋白-1对心肌缺血再灌注损伤的保护作用。《生理科学进展》 2016年第3期。

30． Xu Y, Chen J, Liu Y, Zhang G, Miao G, Wu J, Lu K, Zhao Y, Zhang W, Zheng L, Zhang L, Chen J, Zhou Z, Han Y, Lai P, Guo J, Wu D, Mei S, Zhang L, Zhao Y, Huang W, Wang Y, Tang J, Zhao D, Xian X.The macrophage-derived motor protein KIF13B enhances MERTK-mediated efferocytosis and prevents atherosclerosis in mice. Eur Heart J. 2025 Jul 25:ehaf523. doi: 10.1093/eurheartj/ehaf523 （IF：35.6）

31． Miao GL, Zhang WX, Xu YT, Liu YR, Lai PP, Guo JB, Chen GL, Chen JX, Zhou  ZH, Li YW, Zhang C, Ding Y, Zhang LX, Han YF, Chen JX, Wu JD, Zhao YQ, Mei S, Zhao Y, Ma YW, Zhang L, Huang W, Zhao DY, Dong ED, Wang YH, Xian XD. Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease. Mil Med Res. 2025 Mar 4;12(1):11. doi: 10.1186/s40779-025-00594-3.（IF：22.9 ）

32． Chen J, Xu Y, Yu H, Liu Y, Miao G, Han Y, Zheng L, Cai Z, Zhou Z, Chen J, Shi S, Lai P, Zhang W, Zhang L, Mei S, Zhao Y, Zhang L, Huang W, Wang Y, Zhao D, Kong W, Qin Y, Dong E, Xian X.Macrophage-derived KIF13B interacts with USP9X to attenuate abdominal aortic aneurysm development by potentiating TFEB stability.Theranostics. 2025 Aug 16;15(17):9114-9130.（IF：13.3 ）

33． Lai P, Miao G, Zhao Y, Han Y, Li Y, Liu Y, Guo J, Zhang W, Guo X, Xu Y, Zhang L, Chen G, Zhou Z, Mei S, Chen J, Chen J, Xu L, Zhang C, Ding Y, Dou X, Wen S, Lam SM, Shui G, Wang Y, Huang W, Zhao D, Xian X. SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation. Nat Commun. 2025 Mar 11;16(1):2430. doi: 10.1038/s41467-025-57585-0. （IF：15.7 ）

34． Guo M, Xu Y, Dong Z, Zhou Z, Cong NX, Gao M, Huang W, Wang Y, Liu G, Xian X. Inactivation of Apoc3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters. Circ Res. 2020 Sep 21. doi: 10.1161/CIRCRESAHA.120.317686. Online ahead of print. (IF: 14.4)

35． Zhang W., Guo J., Miao G., Chen J., Xu Y., Lai P., Zhang L., Han Y., Lam S.M., Shui G., Wang Y., Huang W., Xian X. Fat-1 ameliorates MAFLD and atherosclerosis through promoting the nuclear localization of PPARα in hamsters. Research. 2025. doi:10.34133/research.0577. （IF=10.7）

36． Guo M, Liu Z, Xu Y, Ma P, Huang W, Gao M, Wang Y, Liu G, Xian X. Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress. ATVB. 2020 Oct 1: ATVBAHA120315265. doi: 10.1161/ATVBAHA.120.315265. Online ahead of print (IF: 6.6)

37． Dong Z, Shi H, Zhao M, Zhang X, Huang W, Wang Y, Zheng Z, Xian X and Liu G*: Loss of LCAT Activity in the Golden Syrian Hamster Elicits Pro-atherogenic Dyslipidemia and Enhanced Atherosclerosis. Metabolism. 2018, 83:245-255.(IF: 6.5)

38． Li H, Han Y, Wang Y, Qi R, Zhang X, Yu M, Tang Y, Wang M, Huang W, Liu X,Shu Y, Rodrigues B, Han M, Liu G*. Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: The effect of authentic triglyceride-rich lipoproteins with and without ApoCIII. Cardiovascular Research. 2015,107(4):579-89. (IF :5.5)

39． Animal models of coronary heart disease. Liao J, Huang W, Liu G*. J Biomed Res. 2015, 20;30. Review

40． Wang J, Xian X, Huang W, Chen L, Wu L, Zhu Y, Fan J, Ross C, Hayden MR, Liu G. Expression of LPL in Endothelial-Intact Artery Results in Lipid Deposition and Vascular Cell Adhesion Molecule-1 Upregulation in Both LPL and ApoE-Deficient Mice. Arterioscler Thromb Vasc Biol. 2007,27(1):197-203.（IF: 6.8）

41． Costerousse O, Allegrini J, Huang W., Alhenc-Gelas F. Angiotensin I-converting enzyme (kininase II) in cardiovascular and renal regulations and diseases (1998). Biol Res. 31(3):161-7. Review.

42． Coutard M., Huang W. and Osborne-Pellegrin M. Heritability of intracerebral hemorrhagic lesions and cerebral aneurysms in the rat . Stroke. 2000,31: 2678-84.

43． Meneton P., Bloch-Faure M., Hagege AA., Ruetten H., Huang W., bergaya S., Ceiler D., Gehring D., Martins I., Salmon G., Boulanger CM., Nussberger J., Crozatier B., Gasc JM., Heudes D., Bruneval P., Doetschman T., Ménard J., Alhenc-Gelas F. Cardiovascular abnormalities with normal boold pressure in tissue kallikrein deficient mice . Proc Natl Acad Sci USA. 2001,98:2634-39.（IF: 9.6）

44． Zhang AH, Gao S, Fan JL, Huang W, Zhao TQ, Liu G. Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression (2004). FEBS Lett. 2004, 570(1-3):25-9.（IF: 3.4）

45． Shi H#, Guo J#, Yu Q, Hou X, Liu L, Gao M, Wei L, Zhang L, Huang W, Wang Y, Liu G, Tontonoz P, Xian X*. CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunol. 2022 Aug 30;13:999470.

46． Xu Y#, Guo J, Zhang L, Miao G, Lai P, Zhang W, Liu L, Hou X, Wang Y, Huang W, Liu G, Gao M*, Xian X*. Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia. Front Cardiovasc Med. 2022 Feb 2;9:840358.

47． Lin X#, Ma P, Yang C, Wang J, He K, Chen G, Huang W, Fan J, Xian X, Wang Y*, Liu G. Dietary-Induced Elevations of Triglyceride-Rich Lipoproteins Promote Atherosclerosis in the Low-Density Lipoprotein Receptor Knockout Syrian Golden Hamster. Front Cardiovasc Med. 2021 Nov 2;8:738060. doi: 10.3389/fcvm.2021.738060. eCollection 2021. PMID: 34796210

48． Lin X#, Zhang W#, Yang C, Ma P, He K, Chen G, Tao Y, Yan H, Yang Z, Zhang L, Fan J, Cui Q, Huang W, Liu G, Xian X*, Wang Y*. Depleting LCAT aggravates atherosclerosis in LDLR-deficient hamster with reduced LDL-Cholesterol level. J Adv Res. 2023 Nov 1:S2090-1232(23)00320-X. doi: 10.1016/j.jare.2023.10.016. Epub ahead of print.