郭宇轩，助理教授，研究员

北京大学医学部心血管研究所PI

联系方式：

办公地址：北医中心实验楼8楼

E-mail:  guo@bjmu.edu.cn

主要学习及工作经历：

2006.9-2010.7    北京大学生命科学学院本科

2010.8-2015.8    约翰霍普金斯大学生物系博士

2015.8-2020.11   波士顿儿童医院/哈佛医学院博士后

主要学术任职：

2020.11-     北京大学基础医学院/心血管研究所PI

研究方向：

心脏发育、心肌病、基因治疗、基因编辑

代表论文（限10篇）：

1. Guo Y, Pu WT, Cardiomyocyte Maturation: New Phase in Development. Circ Res. 2020, Apr 10;126(8):1086-1106.

2. Guo Y, Jardin BD, Zhou P, Sethi I, Akerberg BN, Toepfer CN, Ai Y, Li Y, Ma Q, Guatimosim S, Hu Y, Varuzhanyan G, VanDusen NJ, Zhang D, Chan DC, Yuan GC, Seidman CE, Seidman JG, Pu WT, Hierarchical and stage-specific regulation of cardiomyocyte maturation by serum response factor. Nat Commun. 2018 Sep 21;9(1):3837.

3. Guo Y, Pu WT, Genetic Mosaics for Greater Precision in Cardiovascular Research.Circ Res. 2018 Jun 22;123(1):27-29.

4. VanDusen NJ*, Guo Y*, Gu W, Pu WT, CASAAV: a CRISPR based platform for rapid dissection of gene function in vivo. Curr Protoc Mol Biol. 2017 Oct 2;120:31.11.1-31.11.14.(*Co-first author)

5. Guo Y*, VanDusen NJ*, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT, Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res.2017 Jun 9;120(12):1874-1888.(*Co-first author)

6. Galdos FX*, Guo Y*, Paige SL*, VanDusen NJ*, Wu SM, Pu WT, Cardiac Regeneration: Lessons From Development. Circ Res.2017 Mar 17;120(6):941-959.(*Co-first author)

7. Guo Y, Zheng Y, Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell.2015 Oct 1;26(19):3379-89.

8. Guo Y, Kim Y, Shimi T, Goldman RD, Zheng Y, Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins. Mol Biol Cell.2014 Apr;25(8):1287-97.(Highlighted in MBoC)

9. Guo Y, Zheng Y, Sculpting the nucleus with dynamic microtubules. Dev Cell. 2013 Oct 14;27(1):1-2.