汪丽恒，哲学博士

                                                                             研究员，副教授

                                               北京大学基础医学院心血管所，血管稳态与重构国家重点实验室

联系方式：

办公地址：医学科技楼北楼1210

E-mail: lihengwang@hsc.pku.edu.cn

主要学习及工作经历：

2003.9-2007.7 中国农业大学生物科学专业本科生

2007.8-2009.5 美国阿肯色大学医学院生理与生物物理研究生

2009.8-2015.5 美国哥伦比亚大学营养与代谢生物学博士研究生

2015.6-2016.7   美国哥伦比亚大学儿科博士后

2016.8-2018.6 美国哥伦比亚大学内分泌系博士后

2018.7-2022.8 美国哥伦比亚大学内分泌系助理研究员

2022.9-2023.7 美国纽约西奈山医学院代谢研究所助理教授

2023.8-  北京大学医学部基础医学院心血管所研究员，副教授

主要学术任职：

2014-2015  国际干细胞研究学会会员

2016-2017  美国肥胖研究协会会员

2015-     美国科学促进会会员

2022-  中国华人糖尿病协会会员

2023- 美国糖尿病协会会员

2023-    美国华人生物科学家协会会员

获奖情况：

2019 Regeneron scholarship for the 2019 Cold Spring Harbor Laboratory course “Computational Genomics”

2014 Keystone Symposia scholarship “A Multisystems Perspective”
2012 Travel award of the 2nd International Hyperphagia Conference
2012 Travel award of the NIDDK “Body Fat Disorders” Conference
2011 Marija Chouinard Awards for Excellence in Research, Institute of Human Nutrition, Columbia University (Highest award for IHN student)

研究方向：糖脂代谢稳态的调控

基金来源：

5K01DK123199   09/04/2019-08/31/2024 National Institute of Health/NIDDK

Role: PI

Pilot & Feasibility grant  5/15/2023-5/14/2024  Einstein-Mount Sinai DRC

Role: PI

R03DK138257 (Pending, fundable score) 12/1/2023-11/30/2025 National Institute of Health/NIDDK

Role: PI

海外优青 (中国国家自然科学基金委)  2023-2026

代表论文：

1. Wang L*, Yu J, Zhou Q, Wang X, Mukhanova M, Du W, Sun L, Pajvani UB, Accili D. TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver. Cell Metab. 2022 Jan 4;34(1):158-170. (*第一与共同通讯作者)

2. Wang L*, Liu Y, Stratigopoulos G, Panigrahi SK, Sui L, Zhang Y, LeDuc CA, Glover HJ, De Rosa MC, Burnett LC, Williams DJ, Shang L, Goland R, Tsang SH, Wardlaw SL, Egli D, Zheng D, Doege CA, Leibel RL. Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. J Clin Invest. 2021 Apr 15;131(8):e146287. (*第一与共同通讯作者, 封面文章)

3. Liu Q*, Yu J*, Wang L*, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajbhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. J Hepatol. 2020 Mar:S0168-8278(20)30124-0. (*: 共一作)

4. Wang L, Liu Q, Kitamoto T, Hou J, Qin J, Accili D. Identification of insulin-responsive transcription factors that regulate glucose production by hepatocytes. Diabetes. 2019 Jun; 68(6): 1156-1167.

5. Wang L, De Solis AJ, Goffer Y, Kathryn E. Birkenbach KE, Engle SE, Tanis R , Levenson JM, Li X, Rausch R, Purohit M, Lee J, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight. 2019 Feb; 4(3):e123337.

6. Wang L, Sui L, Panigrahi SK, Meece K, Doege CA, Wardlaw SL, Egli D, Leibel RL. PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. Stem Cell Reports. 2017 Feb; 14;8(2):264-277.

7. Wang L, Egli D, Leibel RL. Efficient generation of hypothalamic neurons from human pluripotent stem cells. Curr Protoc Hum Genet. 2016 Jul; 90:21.5.1-21.5.14.

8. Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest. 2015 Feb;125(2):796-808.

9. Du W, Wang J, Kuo T, Wang L, McKimpson WM, Son J, Watanabe H, Kitamoto T, Lee Y, Creusot RJ, Ratner LE, McCune K, Chen YW, Grubbs BH, Thornton ME, Fan J, Sultana N, Diaz BS, Balasubramanian I, Gao N, Belvedere S, Accili D. Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals. J Clin Invest. 2022 Dec 15;132(24):e162720.

10. He Y, B'nai Taub A, Yu L, Yao Y, Zhang R, Zahr T, Aaron N, LeSauter J, Fan L, Liu L, Tazebay R, Que J, Pajvani U, Wang L, Silver R, Qiang L. PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms. Adv Sci (Weinh). 2022 Nov 17;:e2204190.

11. Accili, D., Du, W., Kitamoto, T. Kuo, T., McKimpson W., Miyachi Y., Mukhanova M., Son J., Wang L. and Watanabe H. Reflections on the state of diabetes research and prospects for treatment. Diabetol Int (2022).

12. Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. Elife. 2021 Jun 22;10.

13. Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest. 2017 Jan; 127(1):293-305.

14. Stratigopoulos G, Martin Carli JF, O'Day DR, Wang L, Leduc CA, Lanzano P, Chung WK, Rosenbaum M, Egli D, Doherty DA, Leibel RL. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metabolism. 2014 May 6;19(5):767-79.

15. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; Suppl 1:S1-S17.

16. Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer SR, Accili D. (2012) Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PPARγ. Cell, 150(3):620-32.

会议或学术报告：

9/2023           北京大学基础医学院药学院交叉学术沙龙

7/2023         第六届生物物理协会代谢生物学分会学术研讨会青年报告人

6/2023          Speaker at Chinese American Diabetes Association Annual meeting,San Diego

5/2023          Lightning talk and session chair at NYC regional diabetes meeting

3/2023          Invited speaker at the DLDRC Seminar at Columbia University

6/2022         Short talk at FASEB-The liver biology conference, New Orleans

1/2022         中国生物物理协会代谢分会代谢鸿论第113讲报告人

12/2021        Cold Spring Harbor Asia Virtual Meeting on Liver Development,Metabolism, Disease & Cancer

06/2019        Invited speaker, The 1st Obesity Prevention and Treatment Conference(Changzhou, Jiangsu, China)

06/2019        Invited speaker, Graduate Seminar Serials, Medicine Research Institute & Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology (Xianning, Hubei, China)

05/2019        Norman Fleischer NYC Regional Diabetes Symposium & Rifkin Lecture:“Foxo-Independent Pathways to Regulate Insulin’s Action  on Hepatic Glucose Production” (Albert Einstein College of Medicine, NYC

05/2015        NYSTEM meeting. “Understanding the Neurophysiology of Obesity Caused by PC1/3 Deficiency with hESC-Derived Hypothalamic Neurons” (The Rockefeller University, New York)

11/2012          Bridge Medical Summit 2012. “Stem cell-based approaches to the neurobiology of obesity in Bardet-Biedl Syndrome.” (Boston, MA)

10/2012        The 26th Annual Prader-Willi Syndrome Association Scientific Conference. “Stem cell-based approaches to theneurobiology of obesity in Bardet-Biedl Syndrome” (Baton Rouge, LA)

10/2011         Columbia University Institute of Human Nutrition Annual Retreat. “Stem cell-based Approaches to the Neurobiology of Ciliopathies associated with Human Obesity” (Columbia University, NY)