赵强 教授

北京大学医学部基础医学院

Email: qiangzhao@bjmu.edu.cn; carlzhao@126.com

电话：010-82805398

北京大学心血管所研究员，血管稳态与重构全国重点实验室PI。先后获得国家杰出青年科学基金（2019）、国家优秀青年科学基金（2015）和天津市杰出青年科学基金（2018）资助。主要从事心血管生物材料与再生医学研究，利用工程材料科学、化学生物学等原理与方法开展交叉研究，发展用于心血管修复再生与心血管疾病治疗的新材料与新技术。主持国家重点研发计划项目、国家自然科学基金重点项目、重大研究计划培育项目等国家级和省部级科研项目20余项。在国际权威学术期刊Science Translational Medicine、Nature Chemical Biology、Nature Communications、Science Advances、Cell Reports等发表SCI收录论文100余篇（其中IF>10论文40余篇），出版著作章节6部，申请并获授权发明多项。先后获得天津市自然科学一等奖（2019）和天津市科技进步二等奖（2016；2021）。担任中国生物医学工程学会理事、中国解剖学会血管分会副主委、中国生物材料学会心血管材料分会常委、中国生物医学工程学会干细胞工程技术分会常委等。目前是Fundamental Research、Medicine Advances、Smart Materials in Medicine等多个期刊编委。

著作章节：

1. Zhao Q. Applications of Injectable Smart Materials in Tissue Engineering. In: Smart Materials for Tissue Engineering: Applications, Edited by Wang Q. RSC, UK, 2017, p67-89.

2. Wang H, Zhao Q*. Fabrication and evaluation of tissue-engineered vascular grafts with hybrid fibrous structure. In: Vascular Tissue Engineering Edited by Zhao F, Leong K. Springer Nature, Switzerland, 2022, 2375:141-152.

3. 赵强，冯国伟，朱大帅，王飞，张然，叶开，李莉，高方莉，孔德领*. 《再生医学：生物材料与组织再生》第十八章—缺血性疾病的组织再生，付小兵，Nicholas A Peppas，顾晓松主编，人民卫生出版社，2021年9月.

代表论文：

1. Wei Y, Jiang H, Li F, Chai C, Xu Y, Xing M, Deng W, Wang H, Zhu Y, Yang S, Yu Y, Wang W, Wei Y, Guo Y, Tian J, Du J, Guo Z*, Wang Y*, Zhao Q*. Extravascular administration of IGF1R antagonists protects against aortic aneurysm in rodent and porcine models. Sci Transl Med 2024, 16: eadh1763.

2. Hou J, Pan Y, Zhu D, Fan Y, Feng G, Wei Y, Wang H, Qin K, Zhao T, Yang Q, Zhu Y, Che Y, Liu Y, Cheng J*, Kong D, Wang PG, Shen J*, Zhao Q*. Targeted delivery of nitric oxide via a “bump-and-hole”-based enzyme-prodrug pair. Nat Chem Biol 2019, 15: 151-60 (recommended by F1000).

3. Zhu D, Hou J, Qian M, Jin D, Hao T, Pan Y, Wang H, Wu S, Liu S, Wang F, Wu L, Zhong Y, Yang Z, Che Y, Shen J, Kong D, Yin M*, Zhao Q*. Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery. Nat Commun 2021, 12: 4501.

4. Hao T, Ji G, Qian M, Li QX, Huang H, Deng S, Liu P, Deng W, Wei Y, He J, Wang S, Gao W, Li T, Cheng J, Tian J, Pan L, Gao F*, Li Z*, Zhao Q*. Intracellular delivery of nitric oxide enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Sci Adv 2023, 9: eadi9967.

5. Wang F, Qin K, Wang K, Wang H, Liu Q, Qian M, Chen S, Sun Y, Hou J, Wei Y, Hu Y, Li Z, Xu Q*, Zhao Q*. Nitric oxide improves regeneration and prevents calcification in bio-hybrid vascular grafts via regulation of vascular stem/progenitor cells. Cell Rep 2022, 39:110981.

6. Huang H, Qian M, Liu Y, Chen S, Li H, Han Z, Han Z, Chen X, Zhao Q*, Li Z*. Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy. eLife 2023, 12:e84820.

7. Midgley AC, Wei Y, Li Z, Kong D, Zhao Q*. Nitric oxide–releasing biomaterial regulation of the stem cell microenvironment in regenerative medicine. Adv Mater 2020, 32: 1805818.

8. Xing M, Wang F, Chu R, Wang H, Sun Y, Qian M, Jiang H, Midgley AC*, Dai G*, Zhao Q*. Localized COUP-TFII pDNA delivery modulates stem/progenitor cell differentiation to enhance endothelialization and inhibit calcification of decellularized allografts. Adv Sci 2024, 12:2409744.

9. Fu E, Qian M, He N, Yin Y, Liu Y, Han Z, Han Z, Zhao Q*, Cao X*, Li Z*. Biomimetic supramolecular assembly with IGF-1C delivery ameliorates inflammatory bowel disease (IBD) by restoring intestinal barrier integrity. Adv Sci 2024, 11:2403075.

10. Hao T, Qian M, Zhang Y, Liu Q, Midgley AC, Liu Y, Che Y, Hou J, Zhao Q*. An injectable dual-function hydrogel protects against myocardial ischaemia/reperfusion injury by modulating ROS/NO disequilibrium. Adv Sci 2022, 9: 2105408 (ESI Highly cited paper).

11. Pan Y, Yang J, Wei Y, Wang H, Jiao R, Moraga A, Zhang Z, Hu Y, Kong D, Xu Q, Zeng L*, Zhao Q*. Histone deacetylase 7-derived peptides play a vital role in vascular repair and regeneration. Adv Sci 2018, 5:1800006.  

12. Issa Bhaloo S, Wu Y, Le Bras A, Yu B, Gu W, Xie Y, Deng J, Wang Z, Zhang Z, Kong D, Hu Y, Qu A, Zhao Q*, Xu Q*. Binding of Dickkopf-3 to CXCR7 enhances vascular progenitor cell migration and degradable graft regeneration. Circ Res 2018, 123:451-66.

13. Feng G, Zhang J, Li Y, Nie Y, Zhu D, Wang R, Liu J, Gao J, Liu N, He N, Du W, Tao H, Xu Y*, Kong D, Zhao Q*, Li Z*. IGF-1C modified hydrogel enhances cell therapy for acute kidney injury. J Am Soc Nephrol 2016, 27: 2357-69 (with editorial and recommended by F1000).

14. Wei Y, Jiang H, Chai C, Liu P, Qian M, Sun N, Gao M, Zu H, Yu Y, Ji G, Zhang Y, Yang S, He J, Cheng J^*, Tian J, Zhao Q*. Endothelium-mimetic surface modification improves antithrombogenicity and enhances patency of vascular grafts in rats and pigs. JACC Basic Transl Sci 2023, 8: 843-61.

15. Qin K, Wang F, Simpson RML, Zheng X, Wang H, Hu Y, Gao Z, Xu Q* , Zhao Q*. Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts. Biomaterials 2020, 257:120226.

16. Wei Y, Wu Y, Zhao R, Zhang K, Midgley AC, Kong D, Li Z*, Zhao Q*. MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia. Biomaterials 2019, 204:13-24.

17. Deng W, Xu Z, Hua T, Ji G, Wang Z, Liu P, Zhang Y, Li S, Chao Y, Qian M, Zhao Q*, Tian J*. Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy. Bioact Mater 2025, 48:29-42.

18. Wang H, Xing M, Deng W, Qian M, Wang F, Wang K, Midgley AC*, Zhao Q*. Anti-Sca-1 antibody-functionalized vascular grafts improve vascular regeneration via selective capture of endogenous vascular stem/progenitor cells. Bioact Mater 2022, 16: 433-50.

19. Qian M, Liu Q, Wei Y, Guo Z, Zhao Q*. In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents. Bioact Mater 2020, 11:1464-7.

20. Cao X, Duan L, Hou H, Liu Y, Chen S, Zhang S, Liu Y, Wang C, Qi X, Liu N, Han Z, Zhang D, Han ZC, Guo Z*, Zhao Q*, Li Z*. IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization. Theranostics 2020, 10:7697-709.