冼勋德 博士 研究员 博士生导师

北大医学部心血管研究所，脂代谢紊乱与代谢性血管疾病实验室负责人

通讯地址：北京市海淀区学院路38号，北京大学心血管研究所

邮政编码：100191

联系电话：10-82801153

电子邮箱： xianxunde@bjmu.edu.cn

教育背景                                                                  

2009/2003-07/2008就读于北京大学，生理学博士

2009/1999-07/2003就读于北京大学，本科

工作经历                                                    

2019年11月至今，北京大学心血管研究所副研究员

2015年月-2019年8月，美国德克萨斯州西南医学中心分子遗传学系，助理教授

2012年7月-2015年8月，美国德克萨斯州西南医学中心分子遗传学系，讲师

2008年11月-2012年6月，美国德克萨斯州西南医学中心分子遗传学系，博士后

2007年7月-2007年10月，加拿大UBC大学分子医学与治疗中心，交流学生

2006年6月，美国安捷伦生物技术公司和斯坦福大学病理学系，访问学者

特邀审稿                                                                

Nature Cell Biology (NCB),

Nature Communications,

Journal of Clinical Investigation (JCI),

Journal of Biological Chemistry (JBC),

Journal of Lipid research (JLR),

Journal of Clinical Endocrinology & Metabolism (JCEM),

Atherosclerosis,

Nutrition & Metabolism,

Translational Neurodegeneration,

Alzheimer’s Research & Therapeutics,

Journal of Molecular Neuroscience,

CNS Neuroscience & Therapeutics (CNSNT),

Journal of Alzheimer’s Disease (JAD),

Genes and Nutrition (GENU),

Cardiovascular Diabetology (CVD),

Metabolic Brain Disease (MEBR),

Pathobiology,

The Chinese Journal of Physiology,

Cardiovascular Pathology (CVP),

American Journal of Cardiology,

European Journal of Pharmacology (EJP),

Experimental and Molecular Pathology,

The American Journal of Alzheimers Disease & Other Dementias,

Pharmaceutical Biology,

Journal of Cardiovascular Pharmacology and Therapeutics,

Pharmaceutical Biology

学术组织任职                                                              

1.美国神经学会Society for Neuroscience (SfN)

2.美国生理学会American Physiological Society (APS)

3.中国病理生理学会Chinese Association of Pathophysiology

2018-2022发表论文

1.Xiao Lin,Wei Zhang,Chun Yang, Ping Ma,Kunxiang He, Gonglie Chen, Yijun Tao,Haizhao Yan,Zhao Yang, Ling Zhang, Jianglin Fan, Qinhua Cui,Wei Huang, George Liu,Xunde Xian^#(corresponding author),Yuhui Wang.Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level.Journal of Advanced Research.doi:10.1016/j.jare.2023.10.016 (IF:10.48)

2. Shi H*,Guo J*, Yu Q, Hou X, Liu L, Gao M,Wei L, Zhang L, Huang W, Wang Y, Liu G,Tontonoz P,Xian X^#(corresponding author). CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunology. 2022.  (IF=8.786).

3.Xu Y*, Guo J*, Zhang L*, Miao G, Lai P, Zhang W, Liu L, Hou X, Wang Y, Huang W, Liu G, Gao M^#, Xian X^#. Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia. Front. Cardiovasc. Med., 02 February 2022 https://doi.org/10.3389/fcvm.2022.840358.(IF=5.847)

4.Liang C, Wang X, Peng K, Lai P, Liu Z, Ma J, Chen X, Liu G, Zheng M, Wang Y, Yang H, Liu G, Xian X#（corresponding author）, Gao M^#. Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia. Oxid Med Cell Longev. 2022 May 24;2022:1889632. doi: 10.1155/2022/1889632. eCollection 2022.(IF=7.31)

5.  Xian X*(First author), Wang Y, Liu G. Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis. Methods Mol Biol. 2022;2419:433-459. doi: 10.1007/978-1-0716-1924-7_26.

6. Pohlkamp T*, Xian, X* (co-first author), Wong C*, Durakoglugil M, Werthmann C, Saido, Evers B, White C, Connor J, Hammer R, Herz J. NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load. eLife. 2021 (In press).(IF=8.713)

7. Guo M, Ma S, Xu Y, Huang W, Gao M, Wu X, Dong X, Wang Y, Liu G, Xian X^#(responding author). Correction of Familial LCAT Deficiency by AAV-hLCAT Prevents Renal Injury and Atherosclerosis in Hamsters-Brief Report. Arterioscler Thromb Vasc Biol.2021.(IF=8.7)

8. Guo M, Liu Z, Xu Y, Ma P, Huang W, Gao M, Wang Y, Liu G,Xian X^#(responding author). Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress. Arterioscler Thromb Vasc Biol. 2020 Oct 1:ATVBAHA120315265. doi: 10.1161/ATVBAHA.120.315265. Online ahead of print.(IF=8.7)

9. Durakoglugil MS, Wasser CR, Wong CH, Pohlkamp T, Xian X, Lane-Donovan C, Fritschle K, Naestle L, Herz J. Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP 61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner. J Neurosci. 2021 Sep 1;41(35):7340-7349.(IF=6.7)

10. Wu X, Liu X, Wang H, Zhou Z, Yang C, Li Z, Zhang Y, Shi X, Zhang L, Wang Y, Xian X, Liu G, Huang W. Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice. Front Cardiovasc Med. 2021.(IF=3.6)

11. Wang H, Huang X, Xu P, Liu X, Zhou Z, Wang F, Li J, Wang Y, Xian X, Liu G, Huang W. Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-κB pathway. Metabolism. 2021.(IF=9.8)

12.Calvier L, Xian X, Lee RG, Sacharidou A, Mineo C, Shaul PW, Kounnas MZ, Tsai S, Herz J. Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. Arterioscler Thromb Vasc Biol.2021.(IF=10.51)

13. Guo M, Xu Y, Dong Z, Zhou Z, Cong NX, Gao M, Huang W, Wang Y, Liu G,Xian X^#（corresponding author）.Inactivation of Apoc3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters. Circ Res. 2020 Nov 6;127(11):1456-1458. doi: 10.1161/CIRCRESAHA.120.317686. Epub 2020 Sep 21.(IF=23.21)

14. Yu Q, Ma X, Wang Y, Shi H, An J, Wang Y, Dong Z, Lu Y, Ge J, Liu G#, Xian X^#, Sun A^#. Dietary Cholesterol Exacerbates Statin-Induced Hepatic Toxicity in Syrian Golden Hamsters and in Patients in an Observational Cohort Study. Cardiovasc Drugs Ther. 2020 Aug 29. doi:10.1007/s10557-020-07060-3. Online ahead of print.

15. Chun Yang, Wenhong Tian, Sisi Ma, Mengmeng Guo, Xiao Lin, Fengying Gao, Xiaoyan Dong, Mingming Gao, Yuhui Wang, George Liu#,Xunde Xian^#（corresponding author）. AAV-mediated ApoC2 gene therapy: reversal of severe hypertriglyceridemia and rescue of neonatal death in ApoC2 deficient hamsters. Molecular Therapy Methods & Clinical Developmemt. 2020 Jul 15;18:692-701. doi:1016/j.omtm.2020.07.011.(IF=5.85)

16. Gao M, Yang C, Wang X, Guo M, Yang L, Gao S, Zhang X, Ruan G, Li X, Tian W, Lu G, Dong X, Ma S, Li W, Wang Y, Zhu H, He J, Yang H, Liu G#,Xian X^#（corresponding author）. ApoC2 Deficiency Elicits Severe Hypertriglyceridemia and Spontaneous Atherosclerosis: A Rodent Model Rescued From Neonatal Death. Metabolism: Clinical and Experimental.2020 Jun 17;154296. doi:10.1016/j.metabol.2020.154296.(IF=5.06)

17. Lili Wei, Haozhe Shi, Xiao Lin, Xin Zhang, Yuhui Wang, George Liu#, Xunde Xian^#（corresponding author）. Impact of Cholesterol on Ischemic Stroke in Different Human-Like Hamster Models: A New Animal Model for Ischemic Stroke Study. Cells. 2019 Sep; 8(9): 1028.(IF=6.0)

18. Jinjie Wang, Kunxiang He, Chun Yang, Xiao Lin, Xin Zhang, Yuhui Wang, George Liu^#, Xunde Xian^#. Dietary Cholesterol Is Highly Associated with Severity of Hyperlipidemia and Atherosclerotic Lesions in Heterozygous LDLR-Deficient Hamsters. Int J Mol Sci. 2019 Jul 18;20(14). pii: E3515. doi: 10.3390/ijms20143515

19. Kunxiang He, Jinjie Wang, Haozhe Shi, Qiongyang Yu, Xin Zhang, Mengmeng Guo, Yuhui Wang, Xunde Xian# （corresponding author）and George Liu#. An interspecies study of lipid profile and atherosclerosis in familial hypercholesterolemia animal models with low density lipoprotein receptor deficiency. Am J Transl Res. 2019 May 15;11(5):3116-3127. eCollection 2019

20. Xunde Xian*^#, Theresa Pohlkamp*, Murat S. Durakoglugil, Connie Wong, Jürgen K. Beck, Courtney Lane-Donovan, Joachim Herz^#: Reversal of ApoE4 Induced Recycling Block as a Novel Prevention Approach for Alzheimer's Disease.eLife. 2018 Oct 30;7. pii: e40048.

21. Zhao Dong, Haozhe Shi, Mingming Zhao, Xin Zhang, Wei Huang, Yuhui Wang, Lemin Zheng, Xunde Xian^#（corresponding author） and George Liu^#.Loss of LCAT Activity in the Golden Syrian Hamster Elicits Pro-atherogenic Dyslipidemia and Enhanced Atherosclerosis. Metabolism: Clinical and Experimental. 2018 Mar 8. pii: S0026-0495(18)30069-6.

22. Shirling Tsai, Xunde Xian. IL-33 in murine abdominal aortic aneurysm: a novel inflammatory mediator awaiting clinical translation. J Thorac Dis.2019 11 6 2181-2184