冼勋德
冼勋德
冼勋德 博士 研究员 博士生导师
北京大学心血管研究所研究员，血管稳态与重构全国重点实验室PI，脂代谢紊乱与代谢性心血管疾病实验室主任，国家级海外高层次人才青年项目获得者，北京大学博雅青年学者。主要从事脂质代谢调控与代谢性心血管疾病的研究，建立了一系列拥有我国自主知识产权的脂代谢紊乱的基因工程仓鼠模型，相关研究成果发表在Nature Communications ，Journal of Hepatology, Military Medical Research, Circulation Research，ATVB，PNAS，Theranoastics，Science Signaling，EBioMedicine，Metabolism等国际著名期刊。荣获2020年中国实验动物学会优秀青年人才奖，获得2022年度北京市医学会科技奖一等奖、北京市科协自然科技奖二等奖，获批国际和国家专利10项。目前担任中国病理生理学会动脉粥样硬化委员会常务委员和国际动脉粥样硬化学会中国分会副主席，国际动脉粥样硬化杂志Atherosclerosis和Scientific Reports编委，同时为Nature Cell Biology，Nature Communications，Journal of Clinical Investigation，PNAS等特邀审稿人。
通讯地址：北京市海淀区学院路38号，北京大学心血管研究所
邮政编码：100191
联系电话：10-82801153
电子邮箱： xianxunde@bjmu.edu.cn
教育背景
2009/2003-07/2008就读于北京大学，生理学博士
2009/1999-07/2003就读于北京大学，本科
工作经历
2019年11月至今，北京大学心血管研究所副研究员
2015年月-2019年8月，美国德克萨斯州西南医学中心分子遗传学系，助理教授
2012年7月-2015年8月，美国德克萨斯州西南医学中心分子遗传学系，讲师
2008年11月-2012年6月，美国德克萨斯州西南医学中心分子遗传学系，博士后
2007年7月-2007年10月，加拿大UBC大学分子医学与治疗中心，交流学生
2006年6月，美国安捷伦生物技术公司和斯坦福大学病理学系，访问学者
特邀审稿
Nature Cell Biology (NCB),
Nature Communications,
Journal of Clinical Investigation (JCI),
Journal of Biological Chemistry (JBC),
Journal of Lipid research (JLR),
Journal of Clinical Endocrinology & Metabolism (JCEM),
Atherosclerosis,
Nutrition & Metabolism,
Translational Neurodegeneration,
Alzheimer’s Research & Therapeutics,
Journal of Molecular Neuroscience,
CNS Neuroscience & Therapeutics (CNSNT),
Journal of Alzheimer’s Disease (JAD),
Genes and Nutrition (GENU),
Cardiovascular Diabetology (CVD),
Metabolic Brain Disease (MEBR),
Pathobiology,
The Chinese Journal of Physiology,
Cardiovascular Pathology (CVP),
American Journal of Cardiology,
European Journal of Pharmacology (EJP),
Experimental and Molecular Pathology,
The American Journal of Alzheimers Disease & Other Dementias,
Pharmaceutical Biology,
Journal of Cardiovascular Pharmacology and Therapeutics,
Pharmaceutical Biology
学术组织任职
1.美国神经学会Society for Neuroscience (SfN)
2.美国生理学会American Physiological Society (APS)
3.中国病理生理学会Chinese Association of Pathophysiology
代表性论文
1. Lu K, Xu Y, He L, Zhao Y, Xian X#(corresponding author). Revisiting the Role of CBL in Liver Fibrosis: Unveiling the Antifibrotic Potential of CBLB inhibitor NX-1607. J Hepatol. 2025 Mar 25:S0168-8278(25)00211-9. doi: 10.1016/j.jhep.2025.03.023. Epub ahead of print. PMID: 40139509.
2. Pingping Lai, Guolin Miao, Yinqi Zhao, Yufei Han, Yanwei Li, Yiran Liu, Jiabao Guo, Wenxi Zhang, Xin Guo，Yitong Xu，Lianxin Zhang，Gonglie Chen, Zihao Zhou, Si Mei, Jingxuan Chen, Jinxuan Chen，Luzheng Xu, Chong Zhang, Yang Ding，Xiaoguang Dou, Shengmei Wen, Sin Man Lam, Guanghou Shui，Yuhui Wang，Wei Huang, Dongyu Zhao，Xunde Xian #(corresponding author). SR-A3 suppresses AKT activation to protect against MAFLD by inhibiting XIAP-mediated PTEN degradation. Nature communications. 2025. doi:10.1038/s41467-025-57585-0. （IF=14.7）
3. GuoLin Miao, WenXi Zhang, YiTong Xu, YiRan Liu, PingPing Lai, JiaBao Guo, GongLie Chen, JingXuan Chen, ZiHao Zhou, YanWei Li, Chong Zhang, Yang Ding, LianXin Zhang, YuFei Han, JinXuan Chen, JingDong Wu, YinQi Zhao, Si Mei, Yang Zhao, YuanWu Ma, Ling Zhang, Wei Huang, DongYu Zhao, ErDan Dong, YuHui Wang and Xunde Xian #(corresponding author). Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction‑associated fatty liver disease. Mil Med Res. 2025. doi: 10.1186/s40779-025-00594-3. （IF=16.7）
4. Jiabao Guo, Guolin Miao, Wenxi Zhang, Haozhe Shi, Pingping Lai, Yitong Xu, Lianxin Zhang, Gonglie Chen, Yufei Han, Ying Zhao, George Liu, Ling Zhang, Yuhui Wang, Wei Huang, Xunde Xian #(corresponding author). Depletion of ApoA5 aggravates spontaneous and diet-induced nonalcoholic fatty liver disease by reducing hepatic NR1D1 in hamsters. Theranostics. 2024. doi:10.7150/thno.91084. （IF=12.4）
5. Guolin Miao; Jiabao Guo; Pingping Lai; Wenxi Zhang; Yitong Xu; Jingxuan Chen; Lianxin Zhang; Zihao Zhou; Yufei Han; Gonglie Chen; Jinxuan Chen; Yijun Tao; Lemin Zheng; Ling Zhang; Wei Huang; Yuhui Wang; Xunde Xian #(corresponding author). Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Non-Alcoholic Steatohepatitis and Atherosclerosis in LDLR-/- Hamsters, Research. 2024. doi: 10.34133/research.0363. （IF=8.5）
6. Wenxi Zhang, Jiabao Guo, Guolin Miao, Jingxuan Chen, Yitong Xu, Pingping Lai, Lianxin Zhang, Yufei Han, Sin Man Lam, Guanghou Shui, Yuhui Wang, Wei Huang, Xunde Xian #(corresponding author). Fat-1 ameliorates MAFLD and atherosclerosis through promoting the nuclear localization of PPARα in hamsters. Research. 2025. doi:10.34133/research.0577. （IF=8.5）
7. Mei-jie Chen, Yi-tong Xu, Lu Sun, Zhi-hua Wang, Peter J. Little, Li Wang, Xunde Xian #(corresponding author), Jian-ping Weng, Suo-wen Xu. A Novel Mouse Model of Familial Combined Hyperlipidemia and Atherosclerosis. Acta Pharmacologica Sinica 2024. doi:10.1038/s41401-024-01241-8. （IF=6.9）
8. Yitong Xu, Wenxi Zhang, Jiabao Guo, Jinxuan Chen, Guolin Miao, Lianxin Zhang, Yufei Han, Jingxuan Chen, Ying Zhao, Xunde Xian #(corresponding author). ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR−/− hamsters. Genes & Diseases. 2024. doi: 10.1016/j.gendis.2024.101379. （IF=6.9）
9. Xiao Lin; Wei Zhang; Chun Yang; Ping Ma; Kunxiang He; Gonglie Chen; Yijun Tao; Haizhao Yan; Zhao Yang; Ling Zhang; Jianglin Fan; Qinghua Cui; Wei Huang; George Liu; Xunde Xian #(corresponding author); Yuhui Wang. Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level. J Adv Res. 2023. doi: 10.1016/j.jare.2023.10.016. （IF=11.4）
10. Chenxi Liang; Xiaowei Wang; Kenan Peng; PingPing Lai; Ziwei Liu; Jiaao Ma; Xin Chen; Gang Liu; Mingqi Zheng; Yuhui Wang; Hongyuan Yang; George Liu; Xunde Xian #(corresponding author); Mingming Gao ; Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia, Oxid Med Cell Longev. 2022. doi:10.1155/2022/1889632. （IF=7.31）
11. Haozhe Shi; Jiabao Guo; Qiongyang Yu; Xinlin Hou; Lili Liu; Mingming Gao; Lili Wei; Ling Zhang; Wei Huang; Yuhui Wang; George Liu; Peter Tontonoz; Xunde Xian #(corresponding author). CRISPR/CAS9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunol. 2022. doi: 10.3389/fimmu.2022.999470. （IF=5.7）
12. Pohlkamp T*, Xunde Xian*(cofirst author), Wong C*, Durakoglugil M, Werthmann C, Saido, Evers B, White C, Connor J, Hammer R, Herz J. NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load. eLife. 2021. （IF=6.4）
13. Guo M, Ma S, Xu Y, Huang W, Gao M, Wu X, Dong X, Wang Y, Liu G, Xunde Xian #(corresponding author). Correction of Familial LCAT Deficiency by AAV-hLCAT Prevents Renal Injury and Atherosclerosis in Hamsters-Brief Report. Arterioscler Thromb Vasc Biol.2021. Jul;41(7):2141-2148. （IF=7.4）
14. Guo M, Liu Z, Xu Y, Ma P, Huang W, Gao M, Wang Y, Liu G, Xunde Xian #(corresponding author). Spontaneous Atherosclerosis in Aged LCAT-Deficient Hamsters With Enhanced Oxidative Stress. Arterioscler Thromb Vasc Biol. 2020 Dec 40(12):2829-2836. （IF=7.4）
15. Guo M, Xu Y, Dong Z, Zhou Z, Cong NX, Gao M, Huang W, Wang Y, Liu G, Xunde Xian #(corresponding author). Inactivation of Apoc3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters. Circ Res. 2020 Sep 21. doi: 10.1161/CIRCRESAHA.120.317686. （IF=16.5）
16. Gao M, Yang C, Wang X, Guo M, Yang L, Gao S, Zhang X, Ruan G, Li X, Tian W, Lu G, Dong X, Ma S, Li W, Wang Y, Zhu H, He J, Yang H, Liu G#, Xunde Xian #(corresponding author). ApoC2 Deficiency Elicits Severe Hypertriglyceridemia and Spontaneous Atherosclerosis: A Rodent Model Rescued From Neonatal Death. Metabolism. 2020 Jun 17;154296. doi:10.1016/j.metabol.2020.154296. （IF=10.8）
17. Xunde Xian *#(first author, corresponding author), Theresa Pohlkamp*, Murat S. Durakoglugil, Connie Wong, JÜrgen K. Beck, Courtney Lane-Donovan, Joachim Herz#: Reversal of ApoE4 Induced Recycling Block as a Novel Prevention Approach for Alzheimer's Disease. eLife. 2018 Oct 30;7. pii: e40048. （IF=6.4）
18. Zhao Dong, Haozhe Shi, Mingming Zhao, Xin Zhang, Wei Huang, Yuhui Wang, Lemin Zheng, Xunde Xian #(corresponding author) and George Liu#. Loss of LCAT Activity in the Golden Syrian Hamster Elicits Pro-atherogenic Dyslipidemia and Enhanced Atherosclerosis. Metabolism. 2018 Mar 8. pii: S0026-0495(18)30069-6. （IF=10.8）
19. Xin Guo, Mingming Gao, Yunan Wang, Xiao Lin, Liu Yang, Nathan Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian #(corresponding author)and George Liu#: LDL receptor gene targeted hamsters: a familial hypercholesterolemic rodent model with dominant inheritance characteristics. EBioMedicine 2018 Jan;27:214-224. doi: 10.1016/j.ebiom.2017.12.01. （IF=9.7）
20. Xunde Xian *#(first author, corresponding author), Yinyuan Ding*, Marco Dieckmann*, Li Zhou, Mingxia Liu, John Parks, Robert E Hammer, Philippe Boucher, Shirling Tsai, Joachim Herz#: LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. eLife 2017 Nov 16;6. pii: e29292. doi: 10.7554/eLife.29292（IF=6.4）
21. Yinyuan Ding*, Xunde Xian *#(first author, corresponding author)#, William Holland, Shirling Tsai, Joachim Herz#: Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis. EbioMedicine. 2016;7:135-145. （IF=9.7）
22. Yinyuan Ding1, Linzhang Huang1, Xunde Xian *(cofirst author), Ivan S. Yuhanna, Catherine R. Wasser, Michael Frostcher, Chieko Mineo, Philip W. Shaul. Joachim Herz: Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial adhesion and lesion macrophage accumulationd atherosclerosis. Science Signaling. 2016; 9(419):ra29. （IF=6.7）
23. Chen Y, Durakoglugil MS, Xunde Xian *(cofirst author), Herz J*. ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):12011-6. doi: 10.1073/pnas.0914984107. Epub 2010 Jun 14. PMID: 20547867; PMCID: PMC2900641. （IF=9.4）