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科研成果

2022年心血管所发表论文

郑乐民:

1. In vivo imaging of heart failure with preserved ejection fraction by simultaneous monitoring of cardiac nitric oxide and glutathione using a three-channel fluorescent probe. Biosens Bioelectron. 2022 Oct (影响因子12.5)责任作者;

2. High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension. Front Cardiovasc Med. 2022 Mar (影响因子5.8)责任作者;

3. Effect of Lipoprotein(a) on Stroke Recurrence Attenuates at Low LDL-C (Low-Density Lipoprotein) and Inflammation Levels. Stroke. 2022 Apr (影响因子10.2)责任作者;

4. Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. 1. Nat Commun. 2022 Apr (影响因子17.7)责任作者;

5. Elevated lipoprotein(a) and lipoprotein-associated phospholipase A2 are associated with unfavorable functional outcomes in patients with ischemic stroke. J Neuroinflammation. 2021 Dec (影响因子10.0)责任作者;

冼勋德:

1. Shi H, Guo J, Yu Q, Hou X, Liu L, Gao M, Wei L, Zhang L, Huang W, Wang Y, Liu G, Tontonoz P, Xian X#. CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunol. 2022 Aug 30;13:999470.(影响因子8.786 责任作者

2. Chenxi Liang, Xiaowei Wang, Kenan Peng, Pingping Lai, Ziwei Liu, Jiaao Ma, Xin Chen, Gang Liu, Mingqi Zheng, Yuhui Wang, Hongyuan Yang, George Liu, Xunde Xian#, Mingming Gao#. Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia. Oxid Med Cell Longev. 2022 May 24;2022:1889632.doi: 10.1155/2022/1889632. eCollection 2022. (影响因子5.07责任作者

3. Xian X, Wang Y, Liu G. Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis. Methods Mol Biol. 2022;2419:433-459. doi: 10.1007/978-1-0716-1924-7_26. 第一作者

4. Xu Y, Guo J, Zhang L, Miao G, Lai P, Zhang W, Liu L, Hou X, Wang Y, Huang W, Liu G, Gao M, Xian X#. Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia. Front Cardiovasc Med. 2022 Feb 2;9:840358.(影响因子6.05 责任作者



黄薇:

1. Xu Y, Guo J, Zhang L, Miao G, Lai P, Zhang W, Liu L, Hou X, Wang Y, Huang W, Liu G, Gao M, Xian X*. Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia. Front Cardiovasc Med. 2022 Feb 2;9:840358 1F :6.05 (参与作者)


2. Shi H, Guo J, Yu Q, Hou X, Liu L, Gao M, Wei L, Zhang L, Huang W, Wang Y, Liu G, Tontonoz P, Xian X*. CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate lipid atherosclerosis. Front lmmunol. 2022 Aug 30:13:999470.IF :8.786 (参与作者)


王宇辉:

1. Shi H, Guo J, Yu Q, Hou X, Liu L, Gao M, Wei L, Zhang L, Huang W, Wang Y, Liu G, Tontonoz P, Xian X. CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunol. 2022 Aug 30;13:999470. 参与

2. Xu Y, Guo J, Zhang L, Miao G, Lai P, Zhang W, Liu L, Hou X, Wang Y, Huang W, Liu G, Gao M*, Xian X*. Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia. Front Cardiovasc Med. 2022 Feb 2;9:840358. doi: 10.3389/fcvm.2022.840358. eCollection 2022. 参与

3. Liang C, Wang X, Peng K, Lai P, Liu Z, Ma J, Chen X, Liu G, Zheng M, Wang Y, Yang H, Liu G, Xian X*, Gao M*. Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia. Oxid Med Cell Longev. 2022 May 24;2022:1889632. doi: 10.1155/2022/1889632. eCollection 2022. 参与

4. Xian X, Wang Y, Liu G. Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis. Methods Mol Biol. 2022;2419:433-459. doi: 10.1007/978-1-0716-1924-7_26. 参与


张岩:

1. Yao Y, Li F, Zhang M, Jin L, Xie P, Liu D, Zhang J, Hu X, Lv F, Shang H, Zheng W, Sun X, Duanmu J, Wu F, Lan F, Xiao RP., Zhang Y(张岩). Targeting CaMKII-δ9 Ameliorates Cardiac Ischemia/reperfusion Injury by Inhibiting Myocardial Inflammation. Circ Res, 2022, 130, 887-903. (独立通讯作者,影响因子23.2).

2. Zhang J, Liang R, Wang K, Zhang W, Zhang M, Jin L, Xie P, Zheng W, Shang H, Hu Q, Li J, Chen G, Wu F, Lan F, Wang L, Wang S.Q., Li Y, Zhang Y, Liu J, Lv F, Hu X, Xiao RP., Lei X, Zhang Y(张岩). Novel CaMKII-δ inhibitor hesperadin exerts dual functions to ameliorate cardiac ischemia/reperfusion injury and inhibit tumor growth. Circulation, 2022, 145, 1154-1168. (共同通讯作者,影响因子39.9).

3. Zhang M, Zhang J, Zhang W, Hu Q, Jin L, Xie P, Zheng W, Shang H, Zhang Y(张岩). CaMKII-δ9 induces cardiomyocyte death to promote cardiomyopathy and heart failure. Front Cardiovasc Med, 2022, 8, 820416 (独立通讯作者,影响因子5.8).

4. Feng H, Shen H, Robeson MJ, Wu YH, Wu H.K., Chen GJ, Zhang S, Xie P, Jin L, He Y, Wang Y, Lv F, Hu X, Zhang Y(张岩), Xiao R.P.. MG53 E3 ligase-dead mutant protects diabetic hearts from acute ischemic/reperfusion injury and ameliorates diet-induced cardiometabolic damage. Diabetes, 2022, 71, 298-314 (共同通讯作者,影响因子9.3).

5. Wu Z, Shi Y, Cui Y, Xing X, Zhang L, Liu D, Zhang Y, Dong J, Jin L, Pang M, Xiao RP, Zhu Z, Xiong JW, Tong X, Zhang Y(张岩), Wang S, Tang F, Zhang B. Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Protein Cell, 2022, in press (共同通讯作者,影响因子15.3).


张弘:

1..Lin J, Chen Z, Yang L, Liu L, Yue P, Sun Y, Zhao M, Guo X, Hu X, Zhang Y, Zhang H, Li Y, Guo Y, Dong E. Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation. Front Cell Dev Biol. 2022 Apr 1;10:864516. 合作者

2.Yan Q, Wang M, Xia H, Dai C, Diao T, Wang Y, Hou H, Zhang H, Liu M, Long X. Single-cell RNA-sequencing technology demonstrates the heterogeneity between aged prostate peripheral and transitional zone. Clin Transl Med. 2022 Oct;12(10):e1084. 责任作者


1. Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhuang X, Ma D, Ji L, Li W, Xu S, Pan B*, Zheng L*. Anxa1 in smooth muscle cells protects against acute aortic dissection. Cardiovasc Res. 2022. 118(6):1564-1582 Mar 23:cvab109. doi: 10.1093/cvr/cvab109.  (共同通讯,IF: 13.08)

2Zhao M, Wei H, Li C, Zhan R, Liu C, Gao J, Yi Y, Cui X, Shan W, Ji L, Pan B, Cheng S, Song M, Sun H, Jiang H, Cai J, Garcia-Barrio MT, Chen YE, Meng X, Dong E, Wang DW, Zheng L.Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. Nat Commun. 2022. 13(1):1757. doi: 10.1038/s41467-022-29060-7. (IF: 17.694)

3Zeng Q, Zhao M, Wang F, Li Y, Li H, Zheng J, Chen X, Zhao X, Ji L, Gao X, Liu C, Wang Y, Cheng S, Xu J, Pan B, Sun J, Li Y, Li D, He Y, Zheng L. Integrating Choline and Specific Intestinal Microbiota to Classify Type 2 Diabetes in Adults: A Machine Learning Based Metagenomics Study. Front Endocrinol (Lausanne). 2022 Jun 27; 13:906310. (IF: 6.055)


刘雅涵:

1. Yahan Liu, Yan Liu, Xu Zhang, Li Fang, Beilei Zhao, Nanping Wang*. Activation of Endocannabinoid System Mediates Cardiac Hypertrophy Induced by Rosiglitazone. Acta Pharmacologica Sinica. 2022 Sep;43(9):2302-2312. IF: 7.2.


2. Haohsiang Wu, Siamak Amirfakhri, Hsin-Hung Lin, Hannah Hollandsworth, Filemoni Filemoni, Yahan Liu, Yiqian Wu, Julie Y S Li, Hongquan Xu, Shu Chien*, Michael Bouvet, Yingxiao Wang*. Monocytes engineered with iSNAP inhibit human B-lymphoma progression. Bioeng Transl Med. 2022 Jan 12;7(2):e10285. IF: 7.09.


3. Qin Peng*, Ziliang Huang, Kun Sun, Yahan Liu, Chi Woo Yoon, Reed E. S. Harrison, Danielle L. Schmitt, Linshan Zhu, Yiqian Wu, Ipek Tasan, Huimin Zhao, Jin Zhang, Sheng Zhong, Shu Chien & Yingxiao Wang*. Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells. Nat Commun

. 2022 Dec 24;13(1):7933.

郭宇轩:

1. Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload. Theranostics. 2022 Oct 3;12(16):7009-7031. IF=11.6,共同通讯作者

2. The LMNA p.R541C mutation causes dilated cardiomyopathy in human and mice. Int J Cardiol. 2022 Sep 15;363:149-158. IF=4.0,共同通讯作者

3. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2022 May 16;cvac077. IF=13.1,共同通讯作者,共同第一作者

4. Engineered extracellular vesicles and their mimics in cardiovascular diseases. J Control Release. 2022 Jul;347:27-43. IF=11.5,合作作者

5. CMYA5 establishes cardiac dyad architecture and positioning. Nat Commun. 2022 Apr 21;13(1):2185. IF=17.7,合作作者

6. Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation. Front Cell Dev Biol. 2022 Apr 1;10:864516. IF=6.1,唯一通讯作者