血管分子生物学及分子血管生物工程学实验室
负责人：汪南平教授
研究方向：
1. 代谢相关疾病及其心血管病变的发病机制: 代谢相关疾病如冠心病(动脉粥样硬化)、高血压、肺动脉高压、糖尿病及脂肪肝等是我国主要高发慢性疾病，其发病机制不明。其病理生理学过程与机体糖脂代谢紊乱及组织反应的失稳态密切相关。利用功能基因组、蛋白质组、代谢物组学、细胞分子生物学及相关整体动物模型从基因、蛋白、代谢物及信号通路等多个层面探讨以上疾病的病理生理学机制，寻找分子预警及治疗的新靶点。
2. 机械生物信号转导的分子机制: 通过研究血流机械剪应力影响血管内皮细胞生物反应的调控机制，探讨介导机械生物信号转导的细胞感受器、传导通路及效应分子。
3. 细胞代谢及基因表达的调控：主要研究领域是细胞糖脂代谢的调控机制，集中在以核激素受体、转录因子介导的转录调节及以非编码RNA介导的转录后调节。
汪南平简介及研究成果：
汪南平，教授，博士生导师。北京大学心血管研究所副所长、糖尿病中心副主任、代谢疾病研究中心副主任、分子心血管学教育部重点实验室副主任。主要研究方向为代谢综合征及其血管并发症的病理生理学研究。1986年毕业于西安医科大学获硕士学位，1994年在北京医科大学（现北京大学医学部）获医学博士学位，在德国柏林自由大学及美国加州大学（河滨及圣地亚哥校区）做博士后及研究助理教授。2003年任北京大学医学部教授。先后主持国家自然科学基金重大项目及科技部973课题等多个项目。兼任亚洲血管生物学会秘书长、中国生理学会学术工作委员会副主任委员、中国病理生理学会受体专业委员会副主任委员、中国生物学会及分子生物学会脂蛋白专业委员会委员；国家自然科学基金委医学部专家咨询委委员。Faculty1000委员、PPAR Research副主编、Nuclear Receptors（亚太区）主编、Circulation Journal副主编、Cardiovasc Drug & Therapy、J Diabetes、世界临床医学(Lancet中文版)等杂志编委。在糖脂代谢调控、血管内皮功能调节以及冠心病、血管再狭窄、糖尿病、脂肪肝发病机制等方面取得了一系列研究成果，发表包括PNAS、Circulation、Hepatology、Diabetes, Circ Res、Hypertension等SCI论文70余篇。研究成果先后被Nature China、Hepatology、Hypertension及《中国科学》作为研究亮点或封面。关于血管microRNA介导血流剪应力血管生物学效应的工作入选国家自然科学基金优秀成果，主持《代谢性核受体与糖脂代谢调控的分子机制》国家自然科学基金重大项目通过结题验收，评估为特优项目。
课题组在研或结题基金：
国家自然科学基金重大项目
国家重大基础研究项目（973）
国家自然科学基金面上项目
中港合作基金
国家自然科学基金委创新群体
国家自然科学青年基金
联系方式：
通讯地址：北京市海淀区学院路38号，北京大学心血管研究所
邮政编码：100191
联系电话（传真）：010-82801146
电子邮箱：npwang@bjmu.edu.cn
研究人员：
李彦辉：助理研究员
刘雅涵：助理研究员
赵蓓蕾：中级技师
学生：
方立：2010级研究生
殷睿映：2010级研究生
王志鹏：2007级北京大学基础医学八年制
张曼：2011级研究生
李京：2013级研究生
王沫：2010级北京大学基础医学八年制
李盈佳：2014级研究生
班艺倩：2014级研究生
实验室已毕业学生：
田建伟博士后 (04-06)空军总医院心内科
曾泉本科实习生(05-06) University of Wisconsin Madison
汤勇本科实习生(05-06) Southern Illinois University School of Medicine
张鹏博士研究生(02-07) 湖北省郧阳医学院
范艳波博士研究生(03-08) University of Michigan Medical Center
李媛媛硕士研究生(05-08) 山东省滕州市人民医院内科
唐植辉博士研究生(04-09) 北京市卫生局
王颖博士研究生(04-09) 首都医科大学附属安贞医院
李晶珏硕士研究生(06-09) 通用电气有限公司
林连君博士研究生(09-10) 北京大学第一医院
孙丹博士研究生(09-10) 北京大学第一医院
夏龙硕士研究生(07-10) Thermo Scientific公司
郝广华博士后(08-10) 西安交通大学第二附属医院
史晓姗本科实习生(09-10) New York University
王珊本科实习生(09-10) 北京协和医学院
刘奥本科实习生(09-11) 美国宾夕法尼亚大学
刘雅涵博士研究生(08-12) 北京大学医学部
毛光楣博士研究生(09-13) University of Michigan Medical Center
刘炎博士研究生(10-13) University of Michigan Medical Center
黄雅姿博士研究生(08-13)
方希 博士研究生 （2014）
文章：
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9. Wang, Y., et al., The g0/g1 switch gene 2 is an important regulator of hepatic triglyceride metabolism. PLoS One, 2013. 8(8): p. e72315.
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49. Chen, M., et al., ROS and NF-kappaB but not LXR mediate IL-1beta signaling for the downregulation of ATP-binding cassette transporter A1. Am J Physiol Cell Physiol, 2007. 292(4): p. C1493-501.
50. Ai, D., et al., Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A, 2007. 104(21): p. 9018-23.
51. Wu, C.C., et al., Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow. J Cell Biochem, 2006. 98(3): p. 632-41.
52. Wang, N., et al., Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun, 2006. 341(4): p. 1244-51.
53. Dai, J., et al., Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. Free Radic Biol Med, 2006. 41(10): p. 1566-77.
54. Ball, A., et al., Phorbol ester treatment of human myometrial cells suppresses expression of oxytocin receptor through a mechanism that does not involve activator protein-1. Am J Physiol Endocrinol Metab, 2006. 291(5): p. E922-8.
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56. Yan, H., et al., Superior neovascularization and muscle regeneration in ischemic skeletal muscles following VEGF gene transfer by rAAV1 pseudotyped vectors. Biochem Biophys Res Commun, 2005. 336(1): p. 287-98.
57. Wu, C.C., et al., Mechanotransduction in the regulation of collagen and osteopontin gene expressions in human osteoblasts by different shear flow patterns. Faseb Journal, 2005. 19(4): p. A762-A762.
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59. Wu, J., et al., Liver X receptor-alpha mediates cholesterol efflux in glomerular mesangial cells. American Journal of Physiology-Renal Physiology, 2004. 287(5): p. F886-F895.
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